People who have had a stroke are around twice as likely to develop dementia, according to the largest study of its kind ever conducted.
The University of Exeter Medical School led the study which analysed data on stroke and dementia risk from 3.2 million people across the world. The link between stroke and dementia persisted even after taking into account other dementia risk factors such as high blood pressure, diabetes and cardiovascular disease. Their findings give the strongest evidence to date that having a stroke significantly increases the risk of dementia. The study builds on previous research which had established the link between stroke and dementia, though had not quantified the degree to which stroke actually increased dementia risk.
To better understand the link between the two, researchers analysed 36 studies where participants had a history of stroke, totalling data from 1.9 million people. In addition, they analysed a further 12 studies that looked at whether participants had a recent stroke over the study period, adding a further 1.3 million people. The new research, published in the leading dementia journal Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, is the first meta-analysis in the area.
Dr Ilianna Lourida, of the University of Exeter Medical School, said: “We found that a history of stroke increases dementia risk by around 70%, and recent strokes more than doubled the risk. Given how common both stroke and dementia are, this strong link is an important finding. Improvements in stroke prevention and post-stroke care may therefore play a key role in dementia prevention.”
According to the World Health Organisation, 15 million people have a stroke each year. Meanwhile, around 50 million people globally have dementia – a number expected to almost double over 20 years, reaching 131 million by 2050.
Stroke characteristics such as the location and extent of brain damage may help to explain variation in dementia risk observed between studies, and there was some suggestion that dementia risk may be higher for men following stroke.
Further research is required to clarify whether factors such as ethnicity and education modify dementia risk following stroke. Most people who have a stroke do not go on to develop dementia, so further research is also needed to establish whether differences in post-stroke care and lifestyle can reduce the risk of dementia further.
Dr David Llewellyn, from the University of Exeter Medical School, concluded: “Around a third of dementia cases are thought to be potentially preventable, though this estimate does not take into account the risk associated with stroke. Our findings indicate that this figure could be even higher, and reinforce the importance of protecting the blood supply to the brain when attempting to reduce the global burden of dementia.
Also read : How To Counter Dementia
Facts on Stroke-Related Dementia
Stroke (“brain attack”) is a disease of the blood vessels in and around the brain. It occurs when part of the brain does not receive enough blood to function normally and the cells die (infarction), or when a blood vessel ruptures (hemorrhagic stroke). Infarction is more common than hemorrhage and has a number of causes; for example, a vessel (artery) supplying blood to the brain can become blocked by a fatty deposit (plaque), which can form clots and send pieces into vessels further in the brain, or these arteries become thickened or hardened, narrowing the space where the blood flows (atherosclerosis).
The symptoms of stroke vary, depending on which part of the brain is affected. Common symptoms of stroke are sudden paralysis or loss of sensation in part of the body (especially on one side), partial loss of vision or double vision, or loss of balance. Loss of bladder and bowel control can also occur.
Other symptoms include decline in “cognitive” mental functions such as memory, speech and language, thinking, organization, reasoning, or judgment. Changes in behavior and personality may occur. If these symptoms are severe enough to interfere with everyday activities, they are called dementia.
What Causes Stroke-Related Dementia?
Vascular dementia is not a single disease but a group of conditions relating to different vascular problems. What all the conditions have in common is that a critical part of the brain does not receive enough oxygen. The vascular damage underlying stroke-related dementia occurs in several different patterns.
The major cause of the vascular lesions underlying stroke-related dementia is untreated high blood pressure (hypertension). Diabetes, atherosclerosis (hardening of the arteries), heart disease, high cholesterol, peripheral vascular disease, and smoking are other risk factors. Other causes include uncommon vascular diseases.